Pair Name	Gambogic Acid, Doxorubicin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
	Up-regulation	Expression	CDH13	hsa1012
	Up-regulation	Expression	FAS	hsa355
	Down-regulation	Expression	NFKBIA	hsa4792
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	RELA	hsa5970
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vivo Model	Viable A549 cells (5×10⁶/100 ul PBS per mouse) were mixed with 50% Matrigel, and then subcutaneously injected into the right flank of 7- to 8- week old male Balb/c nude mice.
Result	These findings indicate that GA sensitizes lung cancer cells to ADM in vitro and in vivo, providing a rationale for the combined use of GA and ADM in lung cancer chemotherapy.